1. About Abg, General Information, Definition & Quality
Product Info About Abg10+®
What is Abg10+® and what is its botanical source?
Abg10+®, also known as Garlace, It is derived from locally grown Spanish garlic (Allium sativum L.), making it a ‘km 0’ product with minimal carbon emissions.
How is Abg10+® chemically standardized?
The extract is standardized to Agedgarlides®, a proprietary complex (or "totum") of key organosulfur compounds, with a minimum content of 0.12% by HPLC (dry basis).
Which three specific marker compounds define the Agedgarlides® standardization?
The three marker compounds defining the standardization are:
- S-Allyl-L-cysteine (SAC) (≥0.10%)
- S-1-Propenyl-L-cysteine (S1PC) (≥0.10 mg/g)
- S-Allylmercaptocysteine (SAMC) (≥0.10 mg/g)
How is the authenticity and natural origin of Abg10+® confirmed?
Authenticity is guaranteed by the Abg10+® Profile (validating 10 marker compounds). Crucially, the genuineness of SAC is confirmed using LC-IRMS (Liquid Chromatography-Isotope Ratio Mass Spectrometry), which differentiates natural SAC (C3 pathway) from synthetic SAC by measuring carbon isotopic ratios (δ13C).
What is the defining feature of the production process?
It uses a proprietary aging process (controlled temperature/humidity via Maillard reaction) to eliminate unpleasant odor/taste. The extraction employs Active Nature Tech (formerly Abg Cool-Tech), an eco-friendly, low-temperature proprietary process.
2. Recommended Dose and Tradition
Usage Dosage & Tradition
What is the recommended daily dosage for Abg10+®?
The recommended daily dose (standardized to 0.12% Agedgarlides® by HPLC) is 250 mg/day.
What ancient traditional roots support the use of black garlic?
Black garlic has roots in Korea and Japan, with a wellness legacy dating back to Ancient Egypt. It has been trusted by civilizations worldwide as nature's remedy for vitality and balance.
Why does Abg10+® avoid the typical strong garlic odor and taste?
The aging process transforms alliin precursors into SAC, while the compounds responsible for the strong garlic odor break down during aging.
What safety precaution is advised regarding Abg10+® supplementation?
Caution is advised for individuals undergoing anticoagulant treatment, as garlic extracts may affect blood coagulation, especially at high doses or combined with medication.
3. Mechanism of Action
Science How it works
What is the multi-target mechanism of action for cardioprotection?
Abg10+® primarily targets blood pressure, heart function, and oxidative stress. Key components (especially SAC) promote vasodilation, modulate the ACE enzyme, and provide antioxidant capacity.
How does SAC promote vasodilation?
SAC increases the level of eNOS enzyme, responsible for Nitric Oxide (NO) synthesis by the endothelium. Increased NO leads to blood vessel relaxation (vasodilation), improving blood flow and oxygen/nutrient supply.
How does Abg10+® contribute to decreased vasoconstriction?
SAC modulates the Angiotensin-Converting Enzyme (ACE). Reducing ACE activity decreases the formation of Angiotensin II (Ag-II), a potent vasoconstrictor, thereby reducing overall vasoconstriction.
How does Abg10+® directly support heart muscle function?
Ex vivo studies show it increases heart contraction (pumping more blood) and decreases coronary perfusion pressure (indicating coronary artery vasodilation), increasing nutrient and O2 delivery to the heart muscle.
How does Abg10+® inhibit cholesterol synthesis?
It affects lipid metabolism by inhibiting Squalene Monooxygenase (SQLE) and improving ABCA1 activity. This is a secondary mechanism complementary to statins (which typically inhibit HMG CoA).
4. Studies & Scientific Evidence
Research Clinical & lab studies
What evidence supports balancing blood pressure in patients on medication?
A 12-week triple-blind trial (Serrano et al., 2023) on Grade I hypertension patients (already on meds) showed Abg10+® (250 mg/day) induced additional significant reductions: -1.8 mmHg SBP and -1.5 mmHg DBP.
Which mechanistic markers were positively altered in the 12-week study?
Compared to baseline, there was a significant increase in Nitric Oxide (p=0.0254), a significant reduction in ACE activity (p=0.0398), and a significant increase in antioxidant capacity (FRAP) (p=0.0161).
What were the main outcomes in the 6-week study (Valls et al., 2022)?
In 67 individuals with moderate hypercholesterolemia, 250 mg/day significantly decreased DBP (p=0.007), especially in men and those with DBP >75 mmHg. It also significantly reduced serum triglycerides and LDL cholesterol (in the subpopulation with baseline >166 mg/dL).
What are the key pre-clinical results regarding lipids and weight?
In obese rats (high-fat/high-sucrose diet), Abg10+® decreased body weight gain and improved lipid profile (LDL -16%, TG -22%, HDL +46%). It also prevented obesity-induced increases in insulin/leptin and increased adiponectin levels.
