Liboost® is a premium botanical extract made from natural Damiana leaf (Turnera diffusa). It is designed to improve sexual performance. It is distinguished as the first natural, unisex extract for sexual performance.

The raw material comes from Mexico, and the extract is manufactured in Spain. The extraction process is controlled, and the facilities hold GMP certification as well as other quality and environmental management certifications.

The botanical name is Turnera diffusa. The part of the plant used is the leaf.

Liboost® is standardized to ≥1.5% Liboonoides® by HPLC. Liboonoides® is defined as the biomarker complex of bioactive flavonoids found in damiana, which is responsible for its therapeutic activity. These compounds are quantified, ensuring a content between 1.5% and 3.0% by HPLC (dry basis).

The bioactive flavonoids include three main groups: luteolin glycosides, apigenin glycosides, and flavone aglycones.

Because dietary supplements aimed at sexual enhancement have the highest adulteration rates (over 95% of products are adulterated according to the FDA), Pharmactive includes an extra step in its quality analysis to test for the absence of sildenafil in every batch. This ensures the extract's homogeneity and prevents adulteration.

The recommended daily dose of Liboost® is 300 mg/day. This is considered the lowest daily dose on the market.

The use of damiana dates back many centuries. There are reports of its use by the Mayan civilization as an aphrodisiac and to treat "dizziness and loss of balance." The Aztecs also used it as a tonic believed to improve general health and well-being.

Liboost® could act through at least three distinct mechanisms, according to in vitro evidence:

• Nitric Oxide (NO) Release: Liboost® could increase NO release in endothelial tissue, which would promote vasodilation and help improve blood circulation.
• PDE-5 Activity Inhibition: Liboost® could inhibit the key enzyme for cGMP degradation (PDE-5). This inhibition would induce smooth muscle relaxation. In men, this would result in penile erection, and in women, in vaginal smooth muscle relaxation.
• Testosterone Level Balance: Liboost® could inhibit testosterone degradation due to its anti-aromatase activity, maintaining its levels. This would help maintain adequate erectile function in men and adequate sexual desire in both, men and women.

Currently, Liboost does not have clinical studies. Clinical studies should not be confused with consumer studies.

Liboost has one (1) Consumer Study and three (3) in vitro studies.

The mechanisms of action were tested in different in vitro trials performed on human cell lines:

• The extract was able to produce a significant increase in NO release at 10 µg/ml in HUVEC cells.
• It was also able to inhibit PDE-5 and aromatase at concentrations of 1 and 0.5 mg/ml, respectively.
• The research study demonstrated that the standardized commercial extract, Liboost®, presents at least three different mechanisms of action for the potential improvement of sexual dysfunction.

The main objective was to evaluate the beneficial effects of Liboost® on sexual health in both genders. The study was conducted on 60 healthy adults (30 men and 30 women), aged 25 to 60, who were in a stable relationship. The dose used was 300 mg/day for four weeks.

Unisex and gender-specific questionnaires were used:

• SDI (Sexual Desire Inventory) for men and women.
• IIEF (International Index of Erectile Function) for men (evaluates erection, orgasm, desire, intercourse satisfaction, and overall satisfaction).
• FSFI (Female Sexual Function Index) for women (evaluates desire, lubrication, arousal, satisfaction, orgasm, and pain).

Liboost® showed activity across all indicators:

• Sexual Desire (SDI, evaluates interest in sexual activity with a partner and alone): A 45% improvement was observed.
• Men (IIEF): There was a 40% improvement in the International Index of Erectile Function.
• Women (FSFI): There was a 92% improvement in the Female Sexual Function Index.

83% of participants (including men and women) would buy Liboost® after trying it for 4 weeks. 85% of participants would recommend it. Approximately 80% of participants would buy or recommend it.